Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects

Summary

This research study was being done to study the effect of codeine and Naloxegol for 3 days compared to placebo on the movement of food through the colon of healthy individuals. Codeine is a commonly used pain-relieving drug that often causes constipation as an unwanted side effect. Naloxegol is a medication recently approved by the FDA for treatment of constipation induced by Codeine. The hypothesis for this study was that Naloxegol reduces the retardation of small bowel and colonic transit induced by codeine in healthy participants.

Timeline

Start

2016-07-01

Primary completion

2017-05-10

Completion

2017-05-10

Drugs

Indications