Body Composition Changes With Albuterol and Caffeine Versus Placebo in Adolescents

Completed 12 enrolled Pennington Biomedical Research Center Leverage Innovation for Technology Transfer Fund (LSU LIFT2) · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to determine whether taking a combination of caffeine and albuterol three times per day will increase muscle and decrease fat in your child's body and to determine how these medications make your child feel. Albuterol is approved by the FDA for the treatment of asthma. It is not approved to increase muscle and decrease body fat in children.

Timeline

Start: 2016-04
Primary completion: 2017-10-24
Completion: 2017-10-31

Publications

Background Liu AG, Arceneaux KP 3rd, Chu JT, Jacob G Jr, Schreiber AL, Tipton RC, Yu Y, Johnson WD, Greenway FL, Primeaux SD. The effect of caffeine and albuterol on body composition and metabolic rate. Obesity (Silver Spring). 2015 Sep;23(9):1830-5. doi: 10.1002/oby.21163. Epub 2015 Aug 4.
Background Skura CL, Fowler EG, Wetzel GT, Graves M, Spencer MJ. Albuterol increases lean body mass in ambulatory boys with Duchenne or Becker muscular dystrophy. Neurology. 2008 Jan 8;70(2):137-43. doi: 10.1212/01.WNL.0000287070.00149.a9. Epub 2007 Oct 17.
Background Caruso JF, Hamill JL, De Garmo N. Oral albuterol dosing during the latter stages of a resistance exercise program. J Strength Cond Res. 2005 Feb;19(1):102-7. doi: 10.1519/R-14793.1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Caffeine	Small molecule	100 mg	Oral
Subject	Salbutamol	Unknown	4 mg	Oral

Indications

No indication recorded.