drugset / Trial / NCT02754830

A Study of LY3303560 in Healthy Participants and Participants With Alzheimer's Disease (AD)

NCT02754830

Phase 1 Completed 72 enrolled Eli Lilly and Company
RandomizedParallel-groupDouble-blindBasic science

Summary

The purpose of this study is to evaluate the safety and tolerability of the study drug, LY3303560. Side effects and laboratory results will be monitored. This study will involve single doses of LY3303560 administered intravenously (IV), meaning into a vein or subcutaneously (SC), meaning under the skin. Screening is required within 28 days before the start of the study for healthy participants and within 70 days before the start of the study for AD participants. The study requires about 16 weeks of each participant's time including a 4 day clinical research unit (CRU) admission and 10 follow-up appointments. This is the first time that this study drug is being given to participants. This study is for research purposes only, and is not intended to treat any medical condition.

Timeline

Start
2016-04-25
Primary completion
2018-07-10
Completion
2018-07-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Zagotenemab Monoclonal antibody 7 mg Intravenous
Subject Zagotenemab Monoclonal antibody 21 mg Intravenous
Subject Zagotenemab Monoclonal antibody 70 mg Intravenous
Subject Zagotenemab Monoclonal antibody 210 mg Intravenous
Subject Zagotenemab Monoclonal antibody 700 mg Intravenous
Subject Zagotenemab Monoclonal antibody 1400 mg Intravenous
Subject Zagotenemab Monoclonal antibody 2800 mg Intravenous
Subject Zagotenemab Monoclonal antibody 5600 mg Intravenous

Indications