drugset / Trial / NCT02771730

Study to Evaluate the Safety and Immunogenicity of an Oral HIV Vaccine in Healthy, HIV-uninfected Adults

NCT02771730 ↗

RandomizedParallel-groupDouble-blindPrevention

Summary

The purpose of this study is to test experimental human immunodeficiency virus (HIV) vaccines that use an adenovirus vector. The adenovirus vector may help the vaccines stimulate an immune response. Researchers want to see how the immune system will respond to these vaccines as well as if they are safe to give to people. Participants cannot get HIV from these vaccines. However, researchers also want to see if the vaccine's adenovirus is contagious. Adenoviruses cause cold symptoms or mild eye infections, therefore household and intimate contacts will be asked to participate as well.

Timeline

Start
2015-03
Primary completion
2017-02
Completion
2017-02

Outcome

Outcome not reported

Stopped: “Study endpoints not met.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Ad4-EnvC150 Vaccine — Oral
Subject Ad4-mgag Vaccine — Oral
Background AIDSVAX B/E Vaccine 300 ug Intramuscular
Background AIDSVAX B/E Vaccine 600 ug Intramuscular

Indications

No indication recorded.