drugset / Trial / NCT02772978
Dopamine Responsivity in Gamblers
Completed
19 enrolled
University of California, San Francisco
National Center for Responsible Gaming · collab
RandomizedCrossoverTriple-blindBasic science
Summary
This study deals with how people decide between rewards of different value. The investigators want to understand how the brain's dopamine system impacts this kind of decision making. The investigators will use a medication, tolcapone, which can temporarily affect the dopamine system.
Timeline
- Start
- 2014-08
- Primary completion
- 2015-09
- Completion
- 2015-09
Publications
- Background Kayser AS, Allen DC, Navarro-Cebrian A, Mitchell JM, Fields HL. Dopamine, corticostriatal connectivity, and intertemporal choice. J Neurosci. 2012 Jul 4;32(27):9402-9. doi: 10.1523/JNEUROSCI.1180-12.2012.
- Results Kayser AS, Vega T, Weinstein D, Peters J, Mitchell JM. Right inferior frontal cortex activity correlates with tolcapone responsivity in problem and pathological gamblers. Neuroimage Clin. 2016 Dec 20;13:339-348. doi: 10.1016/j.nicl.2016.12.022. eCollection 2017.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Tolcapone | Unknown | — | — |