drugset / Trial / NCT02776514
Steroids, Hyaluronic Acid or Platelet Rich Plasma Versus Placebo for the Knee Osteoarthritis
Phase 2
Completed
120 enrolled
Balgrist University Hospital
Stiftung Marie-Lou Ringgenberg Bern · collabStiftung für Rheumaforschung Zurich · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
This study investigates clinical outcome and imaging outcome parameters after intraarticular injection of steroids, platelet-rich-plasma (prp), hyaluronic acid or placebo in patients with early osteoarthritis of the knee joint.
Timeline
- Start
- 2016-02
- Primary completion
- 2020-11
- Completion
- 2020-11
Publications
- Tschopp M, Pfirrmann CWA, Brunner F, Fucentese SF, Galley J, Stern C, Sutter R, Catanzaro S, Kuhne N, Rosskopf AB. Morphological and Quantitative Parametric MRI Follow-up of Cartilage Changes Before and After Intra-articular Injection Therapy in Patients With Mild to Moderate Knee Osteoarthritis: A Randomized, Placebo-Controlled Trial. Invest Radiol. 2024 Sep 1;59(9):646-655. doi: 10.1097/RLI.0000000000001067. Epub 2024 Feb 28.
- Tschopp M, Pfirrmann CWA, Fucentese SF, Brunner F, Catanzaro S, Kuhne N, Zwyssig I, Sutter R, Gotschi T, Tanadini M, Rosskopf AB. A Randomized Trial of Intra-articular Injection Therapy for Knee Osteoarthritis. Invest Radiol. 2023 May 1;58(5):355-362. doi: 10.1097/RLI.0000000000000942. Epub 2022 Dec 27.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Platelet Rich Plasma | Other / unclassified | 3 ml | Other |
| Comparator | Suplasyn1 | Other / unclassified | 60 mg/ml | Other |
| Comparator | Triamcort | Small molecule | 1 ml | Other |
| Comparator | Triamcort | Small molecule | 40 mg/ml | Other |