Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans

Phase 1 Recruiting 100 enrolled Yale University

RandomizedCrossoverQuadruple-blindBasic science

Summary

The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.

Timeline

Start: 2015-06
Primary completion: 2026-06
Completion: 2026-12

Publications

Mohammad Aghaei A, Urban Spillane L, Pittman B, Flynn LT, De Aquino JP, Bassir Nia A, Ranganathan M. Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study. Psychopharmacology (Berl). 2024 Oct;241(10):2145-2155. doi: 10.1007/s00213-024-06625-6. Epub 2024 Jun 4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dronabinol	Other / unclassified	0.015 mg/kg	Intravenous

Indications

No indication recorded.