Prophylactic Pregabalin to Decrease Pain During Medical Abortion

Phase 4 Completed 110 enrolled University of Hawaii Society of Family Planning · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Medical abortion has been associated with significant pain. The objective of this trial is to determine whether one dose of pregabalin 300 mg, given during medical abortion in addition to the standard of care analgesics, will decrease experienced pain. Investigators will perform a randomized, double-blinded, placebo-controlled trial. Participant pain levels and side effects will be assessed at multiple time points, along with a measure of satisfaction.

Timeline

Start: 2015-06
Primary completion: 2016-10
Completion: 2016-12

Publications

Reynolds-Wright JJ, Woldetsadik MA, Morroni C, Cameron S. Pain management for medical abortion before 14 weeks' gestation. Cochrane Database Syst Rev. 2022 May 13;5(5):CD013525. doi: 10.1002/14651858.CD013525.pub2.
Friedlander EB, Soon R, Salcedo J, Davis J, Tschann M, Kaneshiro B. Prophylactic Pregabalin to Decrease Pain During Medication Abortion: A Randomized Controlled Trial. Obstet Gynecol. 2018 Sep;132(3):612-618. doi: 10.1097/AOG.0000000000002787.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Pregabalin	Small molecule	300 mg	Oral

Indications

No indication recorded.