Curcumin in Preventing Gastric Cancer in Patients With Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia

Summary

This randomized phase IIb trial studies how well curcumin works in preventing gastric cancer in patients with chronic atrophic gastritis and/or gastric intestinal metaplasia. Curcumin is an antioxidant compound found in plants that may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Timeline

Start

2017-04-04

Primary completion

2022-10-06

Completion

2027-04-01

Publications

• Gonzalez-Pons M, Dominguez RL, Montalvan-Sanchez EE, Foster NR, Strand CA, Hernandez-Marrero J, Norwood DA, McMurray RP, Rivera Roman KL, Centeno-Girona H, Rodriguez-Murillo A, Ghandour F, Al Diffalha S, Samadder NJ, Umar A, Richmond E, Rodriguez LM, Limburg PJ, Morgan DR, Cruz-Correa M. Randomized, Double-Blind, Placebo-Controlled Trial of Meriva (Curcuminoids) as a Candidate Chemoprevention Agent for Gastric Carcinogenesis. Cancer Prev Res (Phila). 2026 Jul 1;19(7):403-413. doi: 10.1158/1940-6207.CAPR-25-0363.
• Montalvan-Sanchez EE, Hernandez-Marrero J, Norwood DA, Gonzalez-Pons M, Dominguez RL, Rodriguez LM, Richmond E, Limburg PJ, Cruz-Correa M, Morgan DR. Establishment of a Mesoamerican-Caribbean South-South Research Platform: Challenges in the Meriva (Curcuminoids) Gastric Cancer Chemoprevention Trial. Cancer Prev Res (Phila). 2024 Dec 3;17(12):549-555. doi: 10.1158/1940-6207.CAPR-23-0345.

Drugs

Indications