Cell Therapy by Autologous BMC for Large Bone Defect Repair

Summary

In the present phase-II clinical trial the researchers investigate efficacy and proof of concept of the augmentation with preoperatively isolated autologous BMC cells seeded onto ß-TCP in combination with an angle stable fixation (Philos plate®) for the therapy of proximal humeral fractures.

Timeline

Start

2016-07-02

Primary completion

2019-12-31

Completion

2019-12-31

Publications

• Seebach C, Nau C, Henrich D, Verboket R, Bellen M, Frischknecht N, Moeck V, Eichler K, Horlohe KHS, Hoffmann R, Bonig H, Seifried E, Frank J, Marzi I. Cell-Based Therapy by Autologous Bone Marrow-Derived Mononuclear Cells for Bone Augmentation of Plate-Stabilized Proximal Humeral Fractures: A Multicentric, Randomized, Open Phase IIa study. Stem Cells Transl Med. 2024 Jan 12;13(1):3-13. doi: 10.1093/stcltm/szad067.

Drugs

Indications