ToRsemide for pOstpartum HYpertension

Phase 2 Completed 118 enrolled The University of Texas Health Science Center, Houston

RandomizedParallel-groupQuadruple-blindPrevention

Summary

Currently there is no intervention to prevent persistent postpartum hypertension in preeclamptic women. Physiologically, the use of a pharmacokinetically predictable loop-diuretic is a reasonable intervention to increase elimination of extra fluid accumulated secondary to preeclampsia.The purpose of this study is to assess if Torsemide reduces the incidence of persistent postpartum hypertension in preeclamptic women.

Timeline

Start: 2016-08
Primary completion: 2017-07-28
Completion: 2017-09-09

Outcome

Missed primary endpoint

registry analysis (superiority test); Torsemide vs Placebo; Risk Ratio (RR) 0.76 (95% CI 0.53 to 1.10) NCT02813551 ↗

paper a 5-day course of postpartum torsemide did not have a significant effect on the rate of postpartum hypertension. PMID 30303905 ↗

Publications

Viteri OA, Alrais MA, Pedroza C, Hutchinson M, Chauhan SP, Blackwell SC, Sibai BM. Torsemide for Prevention of Persistent Postpartum Hypertension in Women With Preeclampsia: A Randomized Controlled Trial. Obstet Gynecol. 2018 Nov;132(5):1185-1191. doi: 10.1097/AOG.0000000000002941.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Torsemide	Other / unclassified	20 mg	Oral