drugset / Trial / NCT02826434
Adjuvant PVX-410 Vaccine and Durvalumab in Stage II/III Triple Negative Breast Cancer
Phase 1
Active not recruiting
22 enrolled
Massachusetts General Hospital
AstraZeneca · collabOncoPep, Inc. · collab
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this research study is to evaluate Immunotherapy with a peptide vaccine and Programmed Death Ligand 1 (PD-L1) inhibitor as a possible adjuvant treatment for Stage II or III Triple Negative Breast Cancer. This research study is studying the safety, tolerability, and immune response of these treatments. The names of the study interventions involved in this study are: * PVX-410 Vaccine * Durvalumab (MEDI4736)
Timeline
- Start
- 2016-08-18
- Primary completion
- 2026-12
- Completion
- 2027-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Durvalumab | Monoclonal antibody | — | Intravenous |
| Subject | PVX-410 | Vaccine | — | Intramuscular |
| Background | Hiltonol | Other / unclassified | — | Intramuscular |