Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies

Summary

Severe forms of scabies (crusted scabies and profuse scabies) require a specific treatment. Ivermectin is a recommended treatment in common forms of scabies and represents a promising treatment in crusted scabies in case reports. However, response to ivermectin remains variable among studies, and there is no consensus on the schemes to adopt (dosages and administrations). Ivermectin at 400 µg/kg has already been used, without showing toxicity (in head lice treatment in particular). Investigators propose to demonstrate that 400µg/kg ivermectin dosage will show better efficacy than a 200µg/kg in patients with severe forms of scabies (crusted and profuse).

Timeline

Start

2017-10-11

Primary completion

2022-01-12

Completion

2022-01-12

Publications

• Bernigaud C, Do-Pham G, Guichard E, Beylot-Barry M, Goujon E, Isnard C, Beneton N, Samimi M, Tedbirt B, Adamski H, Azib S, Mahe E, Michel C, Perrot JL, Acquitter M, Bursztejn AC, Chaby G, Caux F, Passeron T, Vanhaecke C, Mahe A, Leccia MT, Barbarot S, Lenormand C, Aubin F, Foulet F, Gregoire L, Giraudeau B, Chosidow O. Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies. N Engl J Med. 2026 May 7;394(18):1814-1823. doi: 10.1056/NEJMoa2411721.

Drugs

Indications