Adjuvanted Inactivated Vaccine Versus Inactivated Influenza Vaccine in Hutterite Children

Phase 4 Completed 3425 enrolled McMaster University University of Calgary · collab University of Saskatchewan · collab

RandomizedParallel-groupTriple-blindPrevention

Summary

This study is a randomized controlled trial (RCT) comparing adjuvanted influenza vaccine (AV) to unadjuvanted inactivated influenza vaccine (IIV). Children in Hutterite colonies in Alberta and Saskatchewan will receive AV or IIV. The goal of this study is to determine whether the AV vaccine, can provide increased community-wide protection.

Timeline

Start: 2016-11
Primary completion: 2019-06
Completion: 2019-07

Publications

Switzer C, Verschoor CP, Pullenayegum E, Singh P, Loeb M. Adjuvant-attenuated symptom severity of influenza infections in vaccinated children. Infect Med (Beijing). 2022 Sep 15;1(3):163-170. doi: 10.1016/j.imj.2022.09.002. eCollection 2022 Sep.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fluad	Vaccine	0.25 ml	Intramuscular
Subject	Fluad	Vaccine	0.5 ml	Intramuscular
Comparator	Influenza Virus Vaccine	Vaccine	0.5 ml	Intramuscular

Adjuvanted Inactivated Vaccine Versus Inactivated Influenza Vaccine in Hutterite Children

Summary

Timeline

Publications

Drugs

Indications