The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production

Phase 1 Completed 23 enrolled Brigham and Women's Hospital

RandomizedCrossoverDouble-blindOther

Summary

The purpose of this research protocol is to determine if the same effects are observed in vivo in humans using a similar approach. Demonstrating that mineralocorticoid acts on zona glomerulosa cells to regulate aldosterone production in a short feedback loop would provide important insight into hormone regulation, and explain variability in pathophysiologic states such as hypertension and cardiovascular diseases.

Timeline

Start: 2016-01
Primary completion: 2019-10
Completion: 2019-12

Publications

Background Braley LM, Williams GH. Rat adrenal cell sensitivity to angiotensin II, alpha-1-24-ACTH, and potassium: a comparative study. Am J Physiol. 1977 Nov;233(5):E402-6. doi: 10.1152/ajpendo.1977.233.5.E402.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Eplerenone	Unknown	100 mg	—
Comparator	Fludrocortisone	Other / unclassified	0.1 mg	—

Indications

No indication recorded.