Predictability Studies on the Efficacy of TNF-α Inhibitors in Chinese RA From "Real World"

Phase 4 Unknown 240 enrolled Fen Li

Non-randomizedParallel-groupOpen-labelBasic science

Summary

Rheumatoid arthritis (RA) is a chronic and disabling disease. tumor necrosis factor-a(TNF-a) inhibitors have demonstrated an outstanding performance in relieving joint inflammation and retarding bone erosion involved in RA. However, there is still about one-thirds of RA patients had a poor response to TNF α inhibitors. The Investigators hope to discover prediction protein with a domestic genetic background and finally establish prediction system with Chinese characteristics.

Timeline

Start: 2016-01
Primary completion: 2019-12
Completion: 2019-12

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Adalimumab	Monoclonal antibody	40 mg	Subcutaneous
Subject	Etanercept	Protein / enzyme biologic	25 mg	Subcutaneous
Subject	Infliximab	Monoclonal antibody	200 mg	Intravenous
Background	Leflunomide	Small molecule	—	—
Background	Methotrexate	Small molecule	10 mg	Oral

Predictability Studies on the Efficacy of TNF-α Inhibitors in Chinese RA From "Real World"

Summary

Timeline

Publications

Drugs

Indications