Follow-up Study for Patients Who Completed Study ALX0681-C301 (Post-HERCULES)

Summary

The objectives of this study were to evaluate long-term safety and efficacy of caplacizumab, to evaluate safety and efficacy of repeated use of caplacizumab and to characterize long-term impact of acquired thrombotic thrombocytopenic purpura (aTTP).

Timeline

Start

2016-10-06

Primary completion

2020-10-23

Completion

2020-10-23

Publications

• Scully M, de la Rubia J, Pavenski K, Metjian A, Knobl P, Peyvandi F, Cataland S, Coppo P, Kremer Hovinga JA, Minkue Mi Edou J, De Passos Sousa R, Callewaert F, Gunawardena S, Lin J. Long-term follow-up of patients treated with caplacizumab and safety and efficacy of repeat caplacizumab use: Post-HERCULES study. J Thromb Haemost. 2022 Dec;20(12):2810-2822. doi: 10.1111/jth.15892. Epub 2022 Oct 21.

Drugs

Indications