Spironolactone After Liver Transplant

Summary

To study spironolactone to prevent calcineurin inhibitor (CNI) kidney injury.

Timeline

Start

2014-12

Primary completion

2018-01

Completion

2018-01

Outcome

Missed primary endpoint

registry analysis (superiority test); SOC-Standard of Care vs Spironolactone; p = 0.0001; Mean Difference (Final Values) 5; Wilcoxon (Mann-Whitney) NCT02883400 ↗

Publications

• Background Russo MW, Krista Bossi, Gale Groseclose, Levi DM, Lon Eskind, Bennett Noell, Anderson WE, Zamor PJ, Vincent Casingal. Estimates of Glomerular filtration rate in liver transplant recipients are not accurate: A role for 24 hour urine creatinine clearance. Archives of Transplantation 2018:2:1-5.

Drugs

Indications