drugset / Trial / NCT02885181

Safety, Tolerability, and Efficacy of GS-9876 in Participants With Active Rheumatoid Arthritis on Background Therapy With Methotrexate

NCT02885181

Phase 2 Completed 83 enrolled Gilead Sciences
RandomizedParallel-groupDouble-blindTreatment

Summary

The primary objective of this study is to evaluate the effect of GS-9876 versus placebo for the treatment of signs and symptoms of rheumatoid arthritis (RA) in participants with active RA as measured by change from baseline in Disease Activity Score for 28 joint count using C-reactive protein (CRP) (DAS28 (CRP)) at Week 12.

Timeline

Start
2016-09-21
Primary completion
2017-08-22
Completion
2017-09-20

Drugs

EvaluationDrugModalityDoseRoute
Subject Filgotinib Small molecule Oral
Subject Lanraplenib Small molecule 10 mg Oral
Subject Lanraplenib Small molecule 30 mg Oral
Background Methotrexate Small molecule Oral

Indications