drugset / Trial / NCT02902120

HCV Treatment Immune Response With Grazoprevir/Elbasvir Before or After Renal Transplant

NCT02902120

Phase 4 Completed 21 enrolled University of Maryland, Baltimore
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to determine whether patients treated for chronic hepatitis C (HCV) with zepatier (grazoprevir/elbasvir) prior to kidney transplant will have a stronger immune response compared to patients treated after kidney transplant. 25 patients with chronic kidney disease (CKD) and HCV will be treated with zepatier and 25 kidney transplant recipients with chronic kidney disease will be treated with zepatier. Blood markers of immune function will be monitored in both groups to determine their response to therapy.

Timeline

Start
2017-05-01
Primary completion
2021-09-01
Completion
2022-06-08

Drugs

EvaluationDrugModalityDoseRoute
Subject Elbasvir Small molecule 50 mg Oral
Subject GRAZOPREVIR ANHYDROUS Small molecule 100 mg Oral