The Role of Nitric Oxide in Cognition in Schizophrenia

Completed 19 enrolled King's College London South London and Maudsley NHS Foundation Trust · collab

RandomizedParallel-groupQuadruple-blindBasic science

Summary

This study evaluates the role of the Nitric Oxide system in cognition in patients with schizophrenia. Participants will be randomised to 2 equal groups and receive either the Nitric Oxide donor molecule glyceryl trinitrate, or a placebo. Performance on several cognitive tasks will be assessed.

Timeline

Start: 2016-09
Primary completion: 2019-04
Completion: 2019-04

Outcome

Missed primary endpoint

paper Compared with placebo, GTN was well tolerated, but was not associated with significant effects on cognition, symptoms, or mood. PMID 32436761 ↗

Publications

Merritt K, Catalan A, Cowley S, Demjaha A, Taylor M, McGuire P, Cooper R, Morrison P. Glyceryl trinitrate in first-episode psychosis unmedicated with antipsychotics: A randomised controlled pilot study. J Psychopharmacol. 2020 Aug;34(8):839-847. doi: 10.1177/0269881120922967. Epub 2020 May 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nitroglycerin	Unknown	0.4 mg	Other