Effect of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Participants

Phase 1 Completed 20 enrolled Bristol-Myers Squibb

NaSingle-groupOpen-labelBasic science

Summary

This study is to evaluate the effects of multiple-dose clarithromycin on the single-dose pharmacokinetics (PK) of apixaban with parameters like Cmax, AUC(INF), and AUC(0-T).

Timeline

Start: 2016-09
Primary completion: 2016-10
Completion: 2016-10

Publications

Garonzik S, Byon W, Myers E, Li X, Marchisin D, Murthy B. The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study. Am J Cardiovasc Drugs. 2019 Dec;19(6):561-567. doi: 10.1007/s40256-019-00348-2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Apixaban	Small molecule	10 mg	Oral
Subject	Clarithromycin	Small molecule	500 mg	Oral

Effect of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Participants

Summary

Timeline

Publications

Drugs

Indications