Atropine in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

Completed 6 enrolled Vanderbilt University

NaSingle-groupOpen-labelOther

Summary

To test the hypothesis that increasing the sinus node rate with atropine treatment prior to exercise will reduce exercise-triggered ventricular ectopy compared to baseline in patients with CPVT.

Timeline

Start: 2016-10
Primary completion: 2019-02
Completion: 2019-02

Outcome

Met primary endpoint

paper Atropine pre-treatment significantly decreased the median number of ventricular ectopic beats from 46 (6-192) to 0 (0-29), P = 0.026; PMID 32091590 ↗

Publications

Kannankeril PJ, Shoemaker MB, Gayle KA, Fountain D, Roden DM, Knollmann BC. Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Europace. 2020 Apr 1;22(4):643-648. doi: 10.1093/europace/euaa029.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atropine	Other / unclassified	0.04 mg/kg	Intravenous