Pediatric Intensive Care Ulcer Prophylaxis Pilot Trial

Phase 3 Completed 116 enrolled McMaster University Canadian Institutes of Health Research (CIHR) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study tests the feasibility of a large study of stress ulcer prophylaxis in critically ill children. Children admitted to the Pediatric Intensive Care Unit who are expected to require mechanical ventilation for more than 48 hours will be randomized to intravenous pantoprazole 1 mg/kg or matching placebo once daily until they no longer need mechanical ventilation.

Timeline

Start: 2017-01-09
Primary completion: 2020-01
Completion: 2020-01

Publications

Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ; Canadian Critical Care Trials Group. Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial. Pilot Feasibility Stud. 2017 May 19;3:26. doi: 10.1186/s40814-017-0142-y. eCollection 2017.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pantoprazole	Other / unclassified	1 mg/kg	Intravenous

Indications

No indication recorded.