Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma

Summary

This research study is designed to see if Capecitabine and Lenvatinib in combination with external radiation therapy are effective in treating locally advanced rectal adenocarcinoma in patients who have not yet had surgery, and what the best dosage is.

Timeline

Start

2016-10-14

Primary completion

2019-10-11

Completion

2020-05-14

Publications

• Mehta R, Frakes J, Kim J, Nixon A, Liu Y, Howard L, Martinez Jimenez ME, Carballido E, Imanirad I, Sanchez J, Dessureault S, Xie H, Felder S, Sahin I, Hoffe S, Malafa M, Kim R. Phase I Study of Lenvatinib and Capecitabine with External Radiation Therapy in Locally Advanced Rectal Adenocarcinoma. Oncologist. 2022 Aug 5;27(8):621-e617. doi: 10.1093/oncolo/oyac003.

Drugs

Indications