Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children

Summary

This is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children. The participating children with acute otitis media are treated wither with amoxicillin, amoxicillin-clavulanate or without antibiotics. The children with allergy to amoxicillin receive a course of macrolide and they will be monitored as a separate group. The main outcomes of this trial are the changes in the intestinal microbiome after the treatment.

Timeline

Start

2016-11

Primary completion

2020-03

Completion

2020-03

Drugs

Indications