drugset / Trial / NCT02940379
A Drug to Drug Interaction Study of Sotagliflozin With Midazolam and Metoprolol
Non-randomizedParallel-groupOpen-labelTreatment
Summary
Primary Objective: To assess the effect of repeated once-daily oral doses of sotagliflozin on CYP2D6 and CYP3A activities using a CYP probe cocktail of metoprolol and midazolam. Secondary Objective: To assess the clinical and laboratory safety of sotagliflozin coadministered with the cocktail probes as compared to that of cocktail probes alone.
Timeline
- Start
- 2016-10
- Primary completion
- 2016-12
- Completion
- 2016-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metoprolol | Other / unclassified | — | Oral |
| Subject | Midazolam | Small molecule | — | Oral |
| Subject | Sotagliflozin | Small molecule | — | Oral |