Multi-dose Vitamin D Supplementation in Preterm Infants

Summary

Preterm newborns are born with lower vitamin D stores. Although vitamin D supplementation is recommended there is no consensus regarding the adequate dose of supplementation for preterm infants.

Timeline

Start

2014-01

Primary completion

2016-12

Completion

2016-12

Outcome

Met primary endpoint

paper 1000IU/d of vitamin D supplementation in preterm infants ≤32weeks gestation age effectively decreases the prevalence of vitamin D deficiency PMID 28779655 ↗

paper concentrations at 36weeks PMA were significantly higher in 800IU (40±21.4ng/ml) and 1000IU group (43±18.9ng/ml) when compared to 400IU group PMID 28779655 ↗

Publications

• Huey SL, Acharya N, Silver A, Sheni R, Yu EA, Pena-Rosas JP, Mehta S. Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age. Cochrane Database Syst Rev. 2020 Dec 8;12(12):CD012875. doi: 10.1002/14651858.CD012875.pub2.
• Bozkurt O, Uras N, Sari FN, Atay FY, Sahin S, Alkan AD, Canpolat FE, Oguz SS. Multi-dose vitamin d supplementation in stable very preterm infants: Prospective randomized trial response to three different vitamin D supplementation doses. Early Hum Dev. 2017 Sep;112:54-59. doi: 10.1016/j.earlhumdev.2017.07.016. Epub 2017 Aug 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vitamin D	Other / unclassified	400 iu	Oral
Subject	Vitamin D	Other / unclassified	800 iu	Oral
Subject	Vitamin D	Other / unclassified	1000 iu	Oral

Indications