drugset / Trial / NCT02946580

Naloxegol for the Prevention of Constipation in Postoperative Spinal Surgery Patients

NCT02946580

Phase 4 Terminated 53 enrolled Massachusetts General Hospital AstraZeneca · collab
RandomizedParallel-groupTriple-blindPrevention

Summary

Constipation is a known complication of the postoperative period after spinal surgery, where prescription pain medicines called opioids are traditionally used in high doses for the treatment of surgery-related pain. The goal of this study is to determine the effectiveness of Movantik (naloxegol)-a FDA-approved drug used to treat constipation that is caused by opioids-in preventing constipation in patients undergoing spinal fusion surgery at MGH.

Timeline

Start
2017-01
Primary completion
2018-02
Completion
2018-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Naloxegol Small molecule 12.5 mg Oral
Subject Naloxegol Small molecule 25 mg Oral

Indications