Evaluation of the Efficiency of Treatment by BUMETANIDE on Autistic Children With a Known Ethiology

Summary

During a previous therapeutic trial, investigators showed that the bumetanide improved significantly autism. This trial showed that a therapeutic response was obtained in 75% of cases. These first results were reinforced by a study led with adult patients for whom the eye tracking measurements as well as the functional MRI showed a diminution of the response time and a modification (amplification) of the cerebral response during an emotions recognition test. Finally, investigators confirmed the physiological mechanism behind the action of the bumetanide in a study in two mouse models of autism.

Timeline

Start

2016-12

Primary completion

2019-12

Completion

2020-06

Drugs

Indications