Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau

Phase 4 Completed 40 enrolled Bandim Health Project Radboud University Medical Center · collab

RandomizedParallel-groupSingle-blindBasic science

Summary

The propose is to test innate immune training in a pilot study of 40 adults \>50 years of age people in Guinea-Bissau. The hypothesis is that BCG vaccination will be associated with increased innate immune training measured as increased cytokine release after in vitro Peripheral Blood Mononuclear Cells (PBMC) stimulation with e.g. Mycobacterium Tuberculosis, Staphylococcus Aureus, Candida Albicans and Streptococcus Pneumoniae.

Timeline

Start: 2017-02-01
Primary completion: 2017-06-15
Completion: 2020-06-15

Publications

Berendsen MLT, Bles P, de Bree LCJ, Jensen KJ, Jensen CC, Wejse C, Mendes DV, Netea MG, Benn CS. Bacillus Calmette-Guerin vaccination induces a trained innate immunity phenotype in adults over 50 years of age: A randomized trial in Guinea-Bissau. Vaccine. 2024 Dec 2;42(26):126439. doi: 10.1016/j.vaccine.2024.126439. Epub 2024 Oct 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bacille Calmette-Guerin	Vaccine	—	Other

Indications

No indication recorded.