Dyslipidemia of Obesity Intervention in Teens

Summary

This trial of pitavastatin will determine efficacy and safety in this high risk population and provide evidence for clinicians to target this treatable risk factor to achieve an impact on early atherosclerosis, and potentially achieve primary prevention of adult cardiovascular disease.

Timeline

Start

2018-05-01

Primary completion

2023-04-21

Completion

2023-06-30

Publications

• de Ferranti SD, Teng JE, Arslanian SA, Atz AM, Brothers JA, Cartoski MJ, Freemon DR, Magge SN, Mahle WT, Mietus-Snyder M, Peterson A, Raghuveer G, Russell MW, Shah AS, Sponseller CA, Stylianou M, Trachtenberg FL, Urbina EM, Ware AL, Zachariah J, Zadokar VV, McCrindle BW; Pediatric Heart Network Investigators. A multicenter trial to test pitavastatin calcium in youth with combined dyslipidemia of obesity: Design, implementation, challenges, and responses. Am Heart J. 2026 Apr;294:107327. doi: 10.1016/j.ahj.2025.107327. Epub 2025 Dec 15.

Drugs

Indications