Genetic Variability in CYP2D6 in U.S Active Duty Population

Phase 1 Completed 550 enrolled Walter Reed Army Institute of Research (WRAIR)

Non-randomizedParallel-groupOpen-labelHealth-services research

Summary

The investigator proposes to 2D6 (Cytochrome P-450 Isoenzyme 2D6) genotype and phenotype a group of active duty service members and assess the effects on primaquine metabolism.

Timeline

Start: 2016-01-08
Primary completion: 2017-07
Completion: 2017-08

Publications

Spring MD, Sousa JC, Li Q, Darko CA, Morrison MN, Marcsisin SR, Mills KT, Potter BM, Paolino KM, Twomey PS, Moon JE, Tosh DM, Cicatelli SB, Froude JW, Pybus BS, Oliver TG, McCarthy WF, Waters NC, Smith PL, Reichard GA, Bennett JW. Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population. J Infect Dis. 2019 Oct 22;220(11):1761-1770. doi: 10.1093/infdis/jiz386.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Primaquine	Small molecule	30 mg	Oral

Indications

No indication recorded.