Oxybutynin Chloride in Managing Hot Flashes
Summary
This randomized phase III trial studies how well oxybutynin chloride works in managing hot flashes in patients who are not candidates for, or not interested in hormone replacement therapy. Previous studies have shown that oxybutynin is effective in managing hot flashes, however doses used in prior studies have resulted in side effects. This trial is evaluating lower doses of oxybutynin with the goal of determining if they are efficacious with less side effects. ADAM-VTE
Timeline
- Start
- 2016-12-09
- Primary completion
- 2018-04-27
- Completion
- 2018-04-27
Outcome
Met primary endpoint
registry analysis (superiority test); Low-dose Oxybutynin Chloride Group vs Placebo Group; p = 0.0041; Kruskal-Wallis NCT02961790 ↗
registry analysis (superiority test); High-dose Oxybutynin Chloride Group vs Placebo Group; p = 0.0001; Kruskal-Wallis NCT02961790 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Oxybutynin | Small molecule | — | Oral |