drugset / Trial / NCT02971345
Endovascular Brachytherapy Combined With Stent Placement and TACE for HCC With Main Portal Vein Tumor Thrombus
Phase 3
Unknown
253 enrolled
Shanghai Zhongshan Hospital
Cancer Institute and Hospital, Chinese Academy of Medical Sciences · collabChanghai Hospital · collabChangzhou Wujin People's Hospital · collabFirst Affiliated Hospital of Zhejiang University · collabFirst Hospital of China Medical University · collabFujian Medical University Union Hospital · collabFujian Provincial Hospital · collabHarbin Medical University · collabHunan Cancer Hospital · collabLanZhou University · collabLishui Country People's Hospital · collabRenJi Hospital · collabRuijin Hospital · collabSecond Affiliated Hospital, School of Medicine, Zhejiang University · collabShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · collabTengzhou Central People's Hospital · collabThe First Affiliated Hospital of Anhui Medical University · collabThe First Affiliated Hospital of Shanxi Medical University · collabThe First Affiliated Hospital of Soochow University · collabThe First Affiliated Hospital of Zhengzhou University · collabThe First Affiliated Hospital with Nanjing Medical University · collabThe Second People's Hospital of Yibin · collabUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology · collabYancheng Third People's Hospital · collabZhejiang University · collabZhongshan Hospital Xiamen University · collabZhuHai Hospital · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
It is a prospective and multi-center clinical research in China to compare the efficacy, safety and related impact factors between TACE alone and endovascular brachytherapy combined with stent placement and TACE for HCC with main portal vein tumor thrombus.
Timeline
- Start
- 2017-01
- Primary completion
- 2020-10
- Completion
- 2020-11
Publications
- Results Luo J, Yan Z, Liu Q, Qu X, Wang J. Endovascular placement of iodine-125 seed strand and stent combined with chemoembolization for treatment of hepatocellular carcinoma with tumor thrombus in main portal vein. J Vasc Interv Radiol. 2011 Apr;22(4):479-89. doi: 10.1016/j.jvir.2010.11.029.
- Results Luo JJ, Zhang ZH, Liu QX, Zhang W, Wang JH, Yan ZP. Endovascular brachytherapy combined with stent placement and TACE for treatment of HCC with main portal vein tumor thrombus. Hepatol Int. 2016 Jan;10(1):185-95. doi: 10.1007/s12072-015-9663-8. Epub 2015 Sep 4.
- Results Yang M, Fang Z, Yan Z, Luo J, Liu L, Zhang W, Wu L, Ma J, Yang Q, Liu Q. Transarterial chemoembolisation (TACE) combined with endovascular implantation of an iodine-125 seed strand for the treatment of hepatocellular carcinoma with portal vein tumour thrombosis versus TACE alone: a two-arm, randomised clinical trial. J Cancer Res Clin Oncol. 2014 Feb;140(2):211-9. doi: 10.1007/s00432-013-1568-0. Epub 2013 Dec 28.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Epirubicin | Small molecule | 30 mg | — |
| Background | Epirubicin | Small molecule | 60 mg | — |
| Background | lipiodol | Unknown | 38 % | — |