Impact of Low-dose Tamoxifen on BPU

Completed 22 enrolled Mayo Clinic

Non-randomizedSingle-groupOpen-labelBasic science

Summary

The study will examine whether changes in background parenchymal uptake (BPU) on molecular breast imaging (MBI) can be induced by short-term use of low-dose tamoxifen. Women who have previously had high BPU on MBI will be recruited. Participants will take low-dose tamoxifen for a 30-day period, with post-tamoxifen MBI in order to investigate the impact of tamoxifen on BPU.

Timeline

Start: 2017-03-01
Primary completion: 2018-02-25
Completion: 2018-11-01

Publications

Hruska CB, Hunt KN, Conners AL, Geske JR, Brandt KR, Degnim AC, Vachon CM, O'Connor MK, Rhodes DJ. Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. Breast Cancer Res. 2019 Mar 8;21(1):38. doi: 10.1186/s13058-019-1120-5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tamoxifen	Small molecule	5 mg	Oral
Subject	Tamoxifen	Small molecule	10 mg	Oral

Indications

No indication recorded.