drugset / Trial / NCT02980068
A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction
Phase 1
Completed
77 enrolled
Gladwin, Mark, MD
National Heart, Lung, and Blood Institute (NHLBI) · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in healthy adult normal volunteers compared to volunteers with PH-HFpEF in the breakdown of oral nitrate.
Timeline
- Start
- 2017-08-28
- Primary completion
- 2022-02-25
- Completion
- 2022-02-25
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 14N Nitrate | Unknown | 11.18 mmol | Oral |
| Subject | 14N Nitrate | Unknown | 1000 mg | Oral |
| Subject | 15N Nitrate | Unknown | 11.8 mmol | Oral |
| Subject | 15N Nitrate | Unknown | 1000 mg | Oral |