Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children

Summary

Several prior studies have demonstrated that medical management of acute appendicitis in adults is a safe first-line therapy option. This study aims to determine whether non-operative management of uncomplicated acute appendicitis with antibiotics is non-inferior to operative management in a pediatric population. This study will be a randomized controlled trial comparing non-operative management with antibiotics to surgical management of uncomplicated acute appendicitis. The hypothesis is that antibiotics are not worse than surgery for the treatment of uncomplicated appendicitis in children.

Timeline

Start

2016-12

Primary completion

2020-12-01

Completion

2020-12-01

Drugs

Indications