drugset / Trial / NCT02996916
Efficacy of Olmesartan on Cerebral Glucose Metabolism, Vascular Inflammation and Adipose Tissue
RandomizedParallel-groupOpen-labelTreatment
Summary
Hypertension is a leading risk factor for morbidity and mortality worldwide. The brain is a major target of the damaging effects of hypertension. Hypertension has been recognized as the leading cause of dementia as well as the most important risk factor for stroke and vascular cognitive impairment. Although glucose is the principal cerebral energy source, impact of hypertensive treatment on cerebral glucose metabolism is poorly understood.
Timeline
- Start
- 2015-12
- Primary completion
- 2018-12
- Completion
- 2020-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amlodipine | Other / unclassified | 2.5 mg | — |
| Comparator | Amlodipine | Other / unclassified | 10 mg | — |
| Comparator | Olmesartan | Other / unclassified | 10 mg | — |
| Comparator | Olmesartan | Other / unclassified | 40 mg | — |
Indications
No indication recorded.