The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion

Summary

The primary objective of the present study is to evaluate the effect of HMG-CoA reductase inhibition during 14 days on the postprandial plasma GLP-1 response in healthy individuals. Secondary objectives include the evaluation of HMG-CoA reductase inhibition on postprandial glucose tolerance, gallbladder emptying, gastric emptying, plasma responses of lipids, bile acids and pancreatic and enteric hormones known to influence glucose metabolism and appetite, and faecal content of bile acids and gut microbiota composition.

Timeline

Start

2016-10

Primary completion

2017-01

Completion

2017-01

Publications

• Thomasen M, Misiakou MA, Li SS, Rodriguez de Evgrafov MC, Lynggaard MB, Karhus ML, Bronden A, Kornholt J, Chavez-Talavera O, Tailleux A, Staels B, Descat A, Hartmann B, Wewer Albrechtsen NJ, Rehfeld JF, Holst JJ, Vilsboll T, Ellegaard AM, Sommer MOA, Sonne DP, Knop FK. Metabolic, enterohepatic and gut microbial effects of atorvastatin in healthy men. Endocr Connect. 2026 Feb 25;15(3):e250721. doi: 10.1530/EC-25-0721. Online ahead of print.

Drugs

Indications