drugset / Trial / NCT03019965
Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis
Completed
426 enrolled
Coordinación de Investigación en Salud, Mexico
Hospital Infantil de Mexico Federico Gomez · collabHospital Regional de Alta Especialidad del Bajio · collabInstituto Mexicano del Seguro Social · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This study evaluates the efficacy and safety of the administration of betalactam antibiotics in prolonged infusion compared to intermittent infusion in children with sepsis. Half of participants will receive piperacillin/tazobactam, imipenem or meropenem in continuous or extended infusion, while the other half will receive piperacillin/tazobactam, imipenem or meropenem in intermittent infusion.
Timeline
- Start
- 2017-02-01
- Primary completion
- 2019-12-30
- Completion
- 2020-01-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | IMIPENEM ANHYDROUS | Small molecule | 20 mg/kg | — |
| Comparator | Meropenem | Small molecule | 33.3333 mg/kg | — |
| Comparator | Piperacillin/tazobactam | Unknown | 75 mg/kg | — |
| Comparator | Piperacillin/tazobactam | Unknown | 300 mg/kg | — |