Effect of Preoperative Clindamycin on Postoperative Endodontic Pain

Summary

The aim of this prospective, randomized, placebo controlled study is to evaluate the effect of clindamycin on post-operative pain and swelling in adult patient with symptomatic apical periodontitis.

Timeline

Start

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Primary completion

2017-12

Completion

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Outcome

Missed primary endpoint

paper No statistically significant difference was found between clindamycin prophylaxis and placebo with regard to the prevention of postoperative infection PMID 16343114 ↗

Publications

• Results Cope A, Francis N, Wood F, Mann MK, Chestnutt IG. Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. Cochrane Database Syst Rev. 2014 Jun 26;(6):CD010136. doi: 10.1002/14651858.CD010136.pub2.
• Results Lindeboom JA, Frenken JW, Valkenburg P, van den Akker HP. The role of preoperative prophylactic antibiotic administration in periapical endodontic surgery: a randomized, prospective double-blind placebo-controlled study. Int Endod J. 2005 Dec;38(12):877-81. doi: 10.1111/j.1365-2591.2005.01030.x.

Drugs

Indications