The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma

Summary

This study aims to assess the effect of inhaled corticosteroids (ICS) on airway smooth muscle (ASM) Na+, K+ pumps in patients with asthma.We wish to investigate differences in Na+, K+ pump content in healthy versus asthmatic patients, whether a reduction in airway hyper-responsiveness observed in asthmatic patients treated with ICS is attributable to an increase in Na+, K+ pump content in ASM cells and compare this in patients with non-eosinophilic asthma versus eosinophilic asthma.

Timeline

Start

2017-03-27

Primary completion

2019-02-28

Completion

2019-02-28

Drugs

Indications