Increased Activity of ENaC in Proteinuric Kidney Transplant Recipients

Completed 14 enrolled University of Southern Denmark Odense University Hospital · collab Region of Southern Denmark · collab

Non-randomizedParallel-groupOpen-labelBasic science

Summary

The aim of this study is to determine if amiloride, a diuretic drug, is capable of increasing renal salt excretion, lowering blood pressure and inhibiting uPA in kidney transplant recipients with proteinuria compared to normoalbuminuric transplant patients.

Timeline

Start: 2017-01-01
Primary completion: 2021-09-01
Completion: 2021-09-01

Publications

Isaksson GL, Hinrichs GR, Andersen H, Bach ML, Weyer K, Zachar R, Henriksen JE, Madsen K, Lund IK, Mollet G, Bistrup C, Birn H, Jensen BL, Palarasah Y. Amiloride Reduces Urokinase/Plasminogen-Driven Intratubular Complement Activation in Glomerular Proteinuria. J Am Soc Nephrol. 2024 Apr 1;35(4):410-425. doi: 10.1681/ASN.0000000000000312. Epub 2024 Jan 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Amiloride	Small molecule	10 mg	—

Indications

No indication recorded.