Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor

Phase 4 Completed 200 enrolled Cairo University

RandomizedParallel-groupTriple-blindPrevention

Summary

A randomized controlled double blinded study included 200 women with preterm contractions. After successful arrest of contractions women were randomized into 2 equal groups: GI women received nifedipine 20 mg tablets twice daily and GII women received Ritodrine 5 mg tablets every 6 hours. The primary outcome was gestational age at delivery and the secondary outcomes include episodes of recurrent preterm labor, mode of delivery, maternal side effects and neonatal outcome

Timeline

Start: 2015-01
Primary completion: 2017-01
Completion: 2017-01

Publications

Wilson A, Hodgetts-Morton VA, Marson EJ, Markland AD, Larkai E, Papadopoulou A, Coomarasamy A, Tobias A, Chou D, Oladapo OT, Price MJ, Morris K, Gallos ID. Tocolytics for delaying preterm birth: a network meta-analysis (0924). Cochrane Database Syst Rev. 2022 Aug 10;8(8):CD014978. doi: 10.1002/14651858.CD014978.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Nifedipine	Other / unclassified	20 mg	Oral
Comparator	Ritodrine	Small molecule	5 mg	Oral

Indications

No indication recorded.