drugset / Trial / NCT03043248
TRK-700 Drug-Drug Interaction Study With Digoxin and Midazolam
Non-randomizedSingle-groupOpen-labelOther
Summary
This study comprises 2 cohorts, and in each cohort, the study will be conducted as an open-label add-on study. The purpose of the study is to investigate the pharmacokinetics of each substrate in concomitant administration of a single dose of the P-glycoprotein substrate digoxin (Cohort A) or the CYP3A4 substrate midazolam (Cohort B) during repeated administration of TRK-700 in healthy adult males.
Timeline
- Start
- 2017-02-06
- Primary completion
- 2017-05-13
- Completion
- 2017-05-21
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Digoxin | Other / unclassified | — | Oral |
| Subject | Midazolam | Small molecule | — | Oral |
| Subject | TRK-700 | Unknown | — | Oral |
Indications
No indication recorded.