Propranolol for Sleep Apnea Therapy

Summary

The primary objective of this study is to test whether a beta blocker, propranolol, lowers the overnight heart rate sleep in obstructive sleep apnea (OSA) during CPAP withdrawal. The secondary objectives are to test whether propranolol influences sleep architecture, morning blood pressure, and vascular function including reactive hyperemia index (RHI) and a marker of arterial stiffness, augmentation index (AIX).

Timeline

Start

2017-02-15

Primary completion

2024-05-01

Completion

2024-05-01

Publications

• Pham LV, Duan D, Badami V, Perin J, Potocki M, Polotsky VY, Jun JC. Propranolol mitigates sleep apnea-related cardiac responses during CPAP withdrawal: a randomized placebo-controlled cross-over clinical study. Sleep Breath. 2026 Mar 11;30(1):88. doi: 10.1007/s11325-026-03645-8.

Drugs

Indications