Effect of Phenazopyridine on Prolapse Surgery Voiding Trials

Phase 3 Completed 152 enrolled University of Massachusetts, Worcester

RandomizedParallel-groupOpen-labelTreatment

Summary

To determine if phenazopyridine reduces the rate of postoperative urinary retention after pelvic organ prolapse surgery.

Timeline

Start: 2017-02-01
Primary completion: 2018-08-28
Completion: 2019-02-28

Outcome

Missed primary endpoint

paper 34% failed without phenazopyridine on postoperative day 1, and 42% failed with phenazopyridine on postoperative day 1 (P = 0.326). PMID 31033527 ↗

Publications

Sierra T, Taylor DL, Leung K, Hall CD, Flynn MK. The Effect of Phenazopyridine on Immediate Postoperative Voiding After Prolapse Surgery: A Randomized Controlled Trial. Female Pelvic Med Reconstr Surg. 2021 Feb 1;27(2):85-89. doi: 10.1097/SPV.0000000000000737.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Phenazopyridine	Small molecule	200 mg	Oral