drugset / Trial / NCT03066453
Evaluation of Short Antibiotic Combination Courses Followed by Aerosols in Cystic Fibrosis
RandomizedCrossoverOpen-labelTreatment
Summary
The aim of this study is to investigate the efficacy of antibiotic therapy with any antibiotic (IV) and IV (Nebcin®) tobramycin for 5 days followed by Solution for nebuliser inhalation (Tobi®) for 9 days and antibiotic cures using 14 days of tobramycin IV. In the case of positive results, the reduction of the duration of IV treatment of tobramycin from 14 days to 5 days would limit the risk of toxicity.
Timeline
- Start
- 2017-06-13
- Primary completion
- 2020-01-16
- Completion
- 2020-01-16
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Tobramycin | Small molecule | 10 mg/kg | Inhaled |
| Subject | Tobramycin | Small molecule | 12 mg/kg | Inhaled |
| Subject | Tobramycin | Small molecule | 15 mg/kg | Inhaled |
| Subject | Tobramycin | Small molecule | 300 mg | Inhaled |