drugset / Trial / NCT03069001
Sofosbuvir and Simeprevir Versus Sofosbuvir and Ribavirin in Treatment of HCV
RandomizedParallel-groupOpen-labelTreatment
Summary
This prospective study was conducted at Ain Shams University Hospital, Internal Medicine, Hepatology and Gastroenterology Department, and Tropical Medicine Department. To compare the efficacy of the combination of sofosbuvir and simeprevir for 12 weeks with the combination of sofosbuvir and ribavirin for 24 weeks in Egyptian patients with HCV-related Child A cirrhosis.
Timeline
- Start
- 2015-06
- Primary completion
- 2016-03
- Completion
- 2016-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ribavirin | Small molecule | 1000 mg | Oral |
| Comparator | Ribavirin | Small molecule | 1200 mg | Oral |
| Comparator | Simeprevir | Small molecule | 150 mg | Oral |
| Comparator | Sofosbuvir | Small molecule | 400 mg | Oral |